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Looking for the next step in obesity pharmacotherapies, the concept of combining entero-pancreatic hormones for obesity treatment was supported by the marked WL, sustained weight maintenance, and metabolic benefits observed with BS, which increase multiple gut hormone levels [9,10,11,12,13,14]

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Stephen Bloom, del Hospital Hammersmith en el Reino Unido, demostr que la inyeccin de GLP-1 directamente en el cerebro de ratas en ayuno resultaba en una reduccin significativa de la ingesta alimentaria, identificando al GLP-1 como un neurotransmisor relevante en el control del apetito